The Megaruptor pumps the sample DNA through an array of uniform hydropores

The Megaruptor pumps the sample DNA through an array of uniform hydropores; the resulting turbulent flow stretches and breaks the DNA strands. Two types of hydropores with specific pore sizes are available. Short hydropores are for fragments from 2 to 9 kb (Fig.

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But the small molecule produced toxic immune reactions in animals, leading the US Food and Drug Administration to put ANA975 on full clinical hold. Dana cautions that because TLR7 is found in nearly all immune cells, it generates a much larger activation ‘footprint’ than TLR9, which is found only in plasmocytes and dendritic cells that combined make up just 1% of the total immune cell population. Thus, side effects from TLR7 activation have the potential to be particularly severe, he says..

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